Drug Treatment Guidelines: Barbiturates


Barbiturate is a drug which acts as a central nervous system depressant, as a result, it produces various effects in the human body from mild sedation to death. First developed in 1864, barbiturates became very common as a recreational drug around the 1960s and 70s. Barbiturates reduce the activity of nerves and also lower the heart rate. They affect a neurotransmitter called as gamma-aminobutyric acid (GABA) which nerves use to communicate with each other. The barbiturates produce the effects similar to the alcohol providing a calming effect on the body. They provide mild relaxation, inability to feel any pain, and unconsciousness. They are present in various physical forms such as tablets, powder, oral solutions and injectable.

Primarily there are types of barbiturates available in the market are –

  • Amobarbital
  • Butabarbital
  • Pentobarbital
  • Secobarbital
  • Belladonna and Phenobarbital
  • Acetaminophen/Caffeine
  • Butalbital/Aspirin.

The barbiturates are used in special cases by doctors such as epilepsy, convulsions, increased pressure in the skull and heavily injured body. In various surgical activities, the barbiturates are also used as an anaesthetic. There are various other uses also which includes insomnia, migraines and trauma.

Side effects
The barbiturates are rarely used because of very small difference between in its safe dose and a deadly dose. However, with prescribed usage, it can cause several side effects such as a headache, drowsiness, relaxation and tiredness. Other serious side effects may include lack of coordination, confusion, loss of memory, respiratory attack and eventual death. These drugs can cause tolerance and dependence on the body.

Interaction with other drugs
The barbiturates should be taken with caution because with some other depressants as it can react and may lead to variation in their effect. Some drugs are –

1. Atazanavir
2. Boceprevir
3. Lurasidone
4. Ranolazine
5. Telaprevir
6. Voriconazole
7. Ritonavir

Type C barbiturates can be given to the pregnant women but it has certain weakening effects on the body. But type D barbiturates are harmful in pregnancy. It is also advised for the nursing mothers to avoid barbiturates because the risk of it reaching their infants through the breastfeeding can’t be totally ruled out. The barbiturates are available at best offers online at Nembutal store pharmacy. You can buy barbiturates online at affordable price.

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